Informações preliminares sobre a ação de produtos farmacêuticos não antibióticos na colonização de Pseudomonas aeruginosa TGC04
DOI:
https://doi.org/10.54038/ms.v3i2.37Palavras-chave:
Pseudomonadas, Produtos farmacêuticos não-antibióticos, Atividade antibiofilmeResumo
Moléculas com propriedades antimicrobianas, tais como os fármacos não-antibióticos, podem pressionar a adaptação de bactérias no ambiente. Nesse trabalho, cinco fármacos não-antibióticos mais vendidos no Brasil e no Egito em 2020 (losartan 50 mg, ácido acetilsalicílico 100 mg, diclofenaco sódico 50 mg, paracetamol 750 mg e metformina 500 mg e dipirona 100 mg/mL), foram testados contra a linhagem selvagem de Pseudomonas aeruginosa TGC04, isolada por nosso grupo e que vem sendo caracterizada ao longo dos anos. Nós avaliamos a inibição da adesão do biofilme durante 48 h, empregando o teste do cristal violeta. A exposição de P. aeruginosa TGC04 aos compostos promoveu uma redução moderada da adesão, semelhante, em todas as drogas testadas, perfazendo cerca de 60%. Isto indicou que as células também estavam moderadamente aderentes. Contudo, apesar de todos os fármacos não-antibióticos não terem produzido um efeito biocida à linhagem selvagem, foi observada uma alta atividade antibiofilme, com exceção do paracetamol.
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