IN SILICO COMPARATIVE ANALYSIS OF SARS-COV-2 MUTATIONS IN BRAZIL
DOI:
https://doi.org/10.54038/ms.v3i3.46Palavras-chave:
Coronavírus, Bioinformática, Pandemia, Proteína espícula, NextcladeResumo
SARS-CoV-2 é um novo coronavírus que surgiu no fim de 2019 na China. Ele causa Covid-19, uma doença que se tornou pandemia semanas depois do primeiro caso e é responsável por infectar e matar milhões de pessoas ao redor do mundo. Desde o primeiro surto, a comunidade científica tem procurado medidas terapêuticas e profiláticas contra a Covid-19. O objetivo desta pesquisa é trazer discussões que possam contribuir para o entendimento do vírus e o desenvolvimento de tratamentos e prevenções contra a doença, além de validar uma metodologia que possa ajudar no entendimento e controle de outros surtos virais. Para este propósito, 5016 amostras de SARS-CoV-2 coletadas no Brasil foram analisadas através de recursos computacionais. Este trabalho apresenta os resultados da árvore filogenética, entropia da informação do genoma e gráficos e tabelas mostrando informações sobre as mutações do SARS-CoV-2 no Brasil. Com base nesses resultados, evidenciou-se a importância da proteína espícula para a alta transmissibilidade do vírus.
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