ATIVIDADE ANTIFÚNGICA DE EXTRATOS DE PLANTAS MEDICINAIS FRENTE A Cryptococcus neoformans: REVISÃO SISTEMÁTICA

Fabricio da Silva Sperandio; Jaine Rodrigues da Rocha; Breno Saldanha Spinelli; Karina Lisita; Anselmo Fortunato Ruiz Rodriguez; Luis Eduardo Maggi

doi:10.54038/ms.v4i1.55

Autores

Fabricio da Silva Sperandio grad. medicina, CCSD, Universidade Federal do Acre, Rio Branco - AC
Jaine Rodrigues da Rocha PPGCSAO, CCBN, Universidade Federal do Acre, Rio Branco - AC https://orcid.org/0000-0003-3681-7322
Breno Saldanha Spinelli grad. medicina, CCSD, Universidade Federal do Acre, Rio Branco - AC
Karina Lisita PPGCSAO, CCBN, Universidade Federal do Acre, Rio Branco - AC
Anselmo Fortunato Ruiz Rodriguez Laboratório de Nanobiotecnologia/BIONORTE/Universidade Federal do Acre, Rio Branco - AC https://orcid.org/0000-0002-3034-183X
Luis Eduardo Maggi Laboratório de Biofísica/CCBN/Universidade Federal do Acre, Rio Branco - AC https://orcid.org/0000-0003-3931-7921

DOI:

https://doi.org/10.54038/ms.v4i1.55

Palavras-chave:

Ação antifúngica, Criptococose, Cryptococcus neoformans, Plantas medicinais, Extratos Vegetais

Resumo

A utilização de plantas no tratamento de doenças é antiga e as observações populares sobre sua utilização e eficácia, podem fornecer informações terapêuticas importantes e cooperar para o desenvolvimento de estudos bem-sucedidos sobre seus efeitos. Apesar do crescente progresso da microbiologia, a criptococose é uma micose oportunista que ainda acomete milhares de pessoas, principalmente pacientes imunocomprometidos. O objetivo do presente trabalho foi realizar uma revisão da literatura científica das principais plantas medicinais com atividades antifúngicas frente a Cryptococcus neoformans. Foram utilizadas as bases de dados Pubmed e Scielo, sendo utilizado os seguintes descritores em Ciências da Saúde: “Medicinal plants” and “Antifungal” and “Cryptococcus”. Ao todo, 22 artigos contemplaram os critérios de inclusão, sendo avaliadas 48 espécies de plantas, de 35 famílias distintas, com 104 fórmulas farmacêuticas produzidas a partir de diferentes metabólitos isolados. Duas espécies obtiveram a melhor atividade antifúngica contra C. neoformans (CIM de 0,63 µg/ml), sendo elas: Gentiana crassicaulis da família Gentianaceae e Prosopis glandulosa da família Leguminosae.

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